PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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Mal-PEG4-Glu(TFP ester)-NH-m-PEG24
0 ImagesCat. No.: HY-140998CAS No.: 2408741-87-5
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Tert-butyl(hex-5-yn-1-yloxy)dimethylsilane
0 ImagesCat. No.: HY-W344269CAS No.: 73448-13-2
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Diethyl heptanedioate
0 ImagesCat. No.: HY-W014126CAS No.: 2050-20-6
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Tert-butyl 4-(hydroxymethyl)-[1,4'-bipiperidine]-1'-carboxylate
![Tert-butyl 4-(hydroxymethyl)-[1,4'-bipiperidine]-1'-carboxylate](https://file.medchemexpress.com/product_pic/hy-w293739.gif "Click to View Tert-butyl 4-(hydroxymethyl)-[1,4'-bipiperidine]-1'-carboxylate Product Detail")
0 ImagesCat. No.: HY-W293739CAS No.: 1215788-48-9
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Ethyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanoate
0 ImagesCat. No.: HY-W115485CAS No.: 302577-73-7
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Methyl N-(3-methoxy-3-oxopropyl)-N-methyl-beta-alaninate
0 ImagesCat. No.: HY-W098612CAS No.: 105-71-5
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Tert-butyl 3-(((methylsulfonyl)oxy)methyl)azetidine-1-carboxylate
0 ImagesCat. No.: HY-W334976CAS No.: 142253-57-4
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3-(4-Carboxyphenyl)propanoic acid
0 ImagesCat. No.: HY-20049CAS No.: 38628-51-2
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21-Bromohenicosanoic acid
0 ImagesCat. No.: HY-W355346CAS No.: 855953-37-6
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5-Oxopentanoic acid
0 ImagesCat. No.: HY-W857147CAS No.: 5746-02-1
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Methyl 13-bromotridecanoate
0 ImagesCat. No.: HY-W773819CAS No.: 80982-86-1
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Piperazin-1-yl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanone
0 ImagesCat. No.: HY-W102314CAS No.: 864754-07-4
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(4-(1H-1,2,3-Triazol-4-yl)phenyl)methanol
0 ImagesCat. No.: HY-168698CAS No.: 2149801-20-5(4-(1H-1,2,3-Triazol-4-yl)phenyl)methanol is a PROTAC Linker. (4-(1H-1,2,3-Triazol-4-yl)phenyl)methanol can be used to synthesize PROTAC Setidegrasib (HY-148273).
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tert-Butyl (3S,4R)-3-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W126674CAS No.: 1610418-19-3
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3-Bromomethyl-cyclobutanecarboxylic acid methyl ester
0 ImagesCat. No.: HY-W295923CAS No.: 89892-95-5
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Ethyl trans-4-(aminomethyl)cyclohexanecarboxylate
0 ImagesCat. No.: HY-W236276CAS No.: 35879-53-9
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tert-Butyl (piperidin-4-ylmethyl)carbamate hydrochloride
0 ImagesCat. No.: HY-W101733CAS No.: 1049727-98-1
